Alopecia UK funds invested: £1,500

When:  October 2020-July 2022

Project type:  Clinical Research

Project Lead:  Dr Tuntas Rayinda

Length of project: 18 months

Research Institute:  King’s College London

Condition of interest:  Male frontal fibrosing alopecia

Funds being used for:  Consumables

Research question:

Is there a genetic basis for male frontal fibrosing alopecia?

Justification for research project:

Frontal fibrosing alopecia is a chronic inflammatory skin condition that leads to permanent hair loss. The condition causes body, facial, eyebrow, and scalp hair loss associated with inflammation and scarring. Frontal fibrosing alopecia is more common in women than in men. A recent study by their group, available here, revealed that there is a strong genetic basis for female frontal fibrosing alopecia, however, the genetic basis of male frontal fibrosing alopecia has not been investigated to date.

The aim of this study is to explore what genes contribute to the development of frontal fibrosing alopecia. The group have managed to recruit the largest cohort of male cases in the UK by collaborating with many other UK sites, in addition to European centres. This project will provide insight into the pathogenesis of male frontal fibrosing alopecia and hopefully enable more research into appropriate and effective treatments.

Who is leading the project:

Dr Tuntas Rayinda is a dermatologist undertaking his clinical PhD research at Kings College London. Dr Rayinda is part of a group which recently published a large-scale genetic study, which identified that the condition in female patients is underpinned by a strong genetic basis.